Brought to you by the Depression Is Real Coalition, The Down & Up Show is dedicated to the reality of depression. Our hosts will talk with some of the world's top experts on depression, as well as people who have been impacted by this illness. The reality of depression is that it is a debilitating and potentially deadly medical condition that affects more than 15 million Americans every year. The other reality of depression is that there is hope.

Darrel A. Regier, M.D., M.P.H.

Dr. Regier has served for the past seven years as Executive Director of the American Psychiatric Institute for Research and Education (APIRE), as well as Director, Division of Research at the American Psychiatric Association (APA). APIRE is an independent 501(c)(3) Research Institute component of the APA, with its own Board of Directors and research mission in mental health services, health policy, epidemiology, and nosology/psychopathology research and research training. It also supports psychiatric education and other career development programs. A principle responsibility has been to coordinate the maintenance and revision plans for the APA's Diagnostic and Statistical Manual.

Dr. Regier received his medical degree from the Indiana University School of Medicine and completed his medical internship at Montefiore Hospital in the Bronx. After a psychiatry residency at the Massachusetts General Hospital (MGH)/Harvard Medical School, he completed his research training at the Harvard School of Public Health and a fellowship at MGH. At the completion of his NIMH service, Dr. Regier retired as a Rear Admiral and Assistant Surgeon General in the Commissioned Corps of the United States Public Health Service