Brought to you by the Depression Is Real Coalition, The Down & Up Show is dedicated to the reality of depression. Each week our hosts will talk with some of the world's top experts on depression, as well as people who have been impacted by this illness. The reality of depression is that it is a debilitating and potentially deadly medical condition that affects more than 15 million Americans every year. The other reality of depression is that there is hope.

Kitty Dukakis

Kitty Dukakis, the wife of former Massachusetts governor and 1988 Democratic presidential nominee Michael Dukakis, is a social worker, a founding member of the United States Holocaust Memorial Council, and an advocate for programs to battle homelessness and promote refugee rights. She revealed her ongoing struggle to overcome depression and her accompanying addictions to alcohol and diet pills in her 1990 memoir, "Now You Know."